There are a couple things that haven't been posted here.

My thoughts:

A2-5: essentially worthless other than a limp in late position. Yes, you are looking for a flush, but that doesn't happen often enough to make a limp from any position profitable long term (from late you can often buy the pot on the flop depending how many see it). Furthermore, what happens when you get that magic 2-pair on a flop of A 2 8, you gotta fear someone limping with pocket 8's (not too likely), or someone limping with A8, and your probably gonna lose your stack, though this wont happen all the time, it will happen enough to make A-baby a reasonably unprofitable hand.

As elipses stated about winning with a wheel, assume you have A3, bunch of limpers, looking like good implied odds for you, flop comes 245, you gotta worry about guys like me that will limp 6-2 in late position dreaming of a situation like this, you must also worry about the guy with 67 who now has an open ended straight draw, you will most likely try to draw some value bets with the confidence you have in your "wheel", this will give him odds to hit his hand, assume an 8 comes on the river, your not gonna see his nut straight coming.

The situations I've detailed are entirely hypothetical, but they happen more often than you think. When they do, you will often lose your entire stack in NL, this is enough to make them unprofitable compared to the tiny pots you win with your A-shitkicker.

Food for thought.