I primarily play Ongame (Pokerroom mainly) $50NL and have also played Stars, Party and Paradise. The main difference I see is that Ongame players play for stacks quite readily while other sites they are much more selective (read: usually only when they have the goods). It is not uncommon for LAGGY players to swing up or down 8 buyins in one couple hour session--right Cardsman? I play a more tight agressvive style therefore my variance is much smaller, between +/- 3 buyins 99% of the time. So, yes there are adjustments that need to be made when going from site to site...however, it is probably best to stick with one site for the long run so you don't have to keep adapting your game every time you move.