22 is good. It beats a Queen high. I mean play any hole cards that -- if they were the only cards in your poker hand -- would beat a Q with a 7.

also, 22 is 52% favorite over Q7off, according to
http://simulator.pokertips.org/simulator.php

Like most strategies, I can't rule it out as "impossible". You just have to know precisely what it is good for. Same thing with hole cards: Axs is not good for pairs -- it's good for flushes.

So: in my opinion a 2-card strategy is good for those games with multiple maniacs, drunks & flirts etc. You can't waste energy trying to analyze the table texture/play patterns in such a game.

I don't know if it's good for much else.