Well there are a few considerations:

1. How often people are just going to call, check turn and when I check the turn back randomly decide to bluff on the river. I see donks take this line with random crap.
2. How often someone is going to c/r as a bluff. This is more likely going to be the BB because once the SB folds he feels safer about his prospects.
3. How happy are we to play for stacks with the SB. If he's a total retard, we might be fist-pump shoving river. Of course this could also apply to the BB, but it's been a while since I've seen people who play so bad that you'd want to do that with a full stack. Shortstackers, however...

If those two are unknown I would go for bet flop, check blank turn, call or b/f river. Small bet sizes.
This is because a cbet is something that's expected and well-known. People peel the flop more than they peel the turn if we delayed cbet.