OP, let the numbers do the talking here when contemplating jamming over a 4bet against a reg. You're not going to be in brilliant shape vs a lot of micro nit regs when you get called (and your database will prove that), but overall it's likely to still be +EV once you factor in fold equity and the fact you're much more likely to get paid off when you do have KK+.

I hate rules, but when 3betting a value hand like AK, I'd say:
- you shouldn't even contemplate calling a 4bet oop 100bb effective, barring maybe AA against a LAG.
- you should be looking to get it in pre against all but the nittiest nit's 4bet (and you'd really need to ask yourself why you were 3betting a value hand in the first place if villain is such a nit.