PLO $100: Second set call or fold?

Full Tilt Pot-Limit Omaha, $1.00 BB (6 handed) - Full-Tilt Converter Tool from FlopTurnRiver.com

UTG ($303.60)
MP ($149.20)
Hero (CO) ($407.95)
Button ($67.40)
SB ($115.95)
BB ($44.55)
Preflop: Hero is CO with , , ,
2 folds, Hero bets $3.50, Button raises to $12, SB calls $11.50, 1 fold, Hero calls $8.50
Flop: ($37) , , (3 players)
SB checks, Hero checks, Button bets $37, SB raises to $103.95 (All-In), Hero ?
I find 2nd and 3rd set very hard to play in Omaha.
Should I call or fold here and why?

Another hand:
Full Tilt Pot-Limit Omaha, $1.00 BB (6 handed) - Full-Tilt Converter Tool from FlopTurnRiver.com

MP ($20.90)
CO ($218.15)
Button ($20.30)
SB ($46.75)
BB ($117.15)
Hero (UTG) ($269.10)
Preflop: Hero is UTG with , , ,
Hero calls $1, 1 fold, CO bets $4.50, 3 folds, Hero calls $3.50
Flop: ($10.50) , , (2 players)
Hero checks, CO bets $10.50, Hero calls $10.50
Turn: ($31.50) (2 players)
Hero bets $15.75, CO raises to $78.75, Hero ?