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Assuming 100bbs deep, the easiest thing to do is to widen your 4b value range and add bluffs. That's just like plain old solid unexploitable poker. Like 4b/call 99+/AQ (or AJs+ or AJo+, depending on how wide they're 3b'ing) and 4b/f any Axo you can't otherwise play profitably. Also, against players who resteal a lot, you should be keeping your raise/folding range as slim as you can. Opening Q7o on the button is a completely different game against a 25/20/15 with a 70% fold to steal as it is from a 25/20/5 with a 70% fold to steal.
Playing exploitively involves merging your range completely (like 77+/good aces/KQs and no bluffs) or not merging it at all (QQ+/AK and a lot of bluffs) and everything in between, based on game dynamics, reads on players, etc. I'd probably just play on small variations on unexploitably until you get a good sample and read on how players react to 4b's (1k hands+) unless there is some situation that makes it so that you can have an incredible feel for dynamics against a particular player (eg: you're playing live or you're at a heads-up table or you're like a Rain Man-style super OCD math guy).
The maths change very quickly as you get deeper (4b/calling becomes a lot pricier as little as like 115bb's deep, but the good news is that as you get like 150+bb's deep, then you can start to widen your 3b calling range which should solve a lot of that problem, and eventually you get deep enough that 4b/5b wars turn into 5b/6b wars). Strategy obviously also changes quite a bit when you're too shallow to be able to 4b without committing yourself to calling off your whole stack. In these spots, you should just be 4b shoving a totally merged range (against 40-50bb short stackers who 3b a lot, you can 4b shove as wide as like 22+/A9+/KJ+/QJs).
NOTE: All ranges in this post are merely examples. I didn't even mention 3b and resteal percentages and this is central to deciding how much we need to 4b in the first place, so if someone's only restealing like 8%, then you should be shaving a considerable number of combos from that 99+/AQ+/AJs + all aces you can't call with range, as opposed to if you're facing someone who resteals like 15%. Basically the more villain 3b's and the more exploitable their tendencies when facing 4b'ing is, the more you should 4b. All of my other factors get into what kind of hands you should 4b.
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