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No matter what you should be trying to isolate him - playing any hand multiway is just going to get you in trouble. If you want to take a high risk/high reward scenario then just start 3-betting any playable hand and be willing to make thin calls for big pots.
If you to take a low risk/high reward scenario then just do what everyone else is doing and wait for big hands and let him blow up.
You are in the best position because you can do whatever you want since you are directly to his left. So you should also get plenty of opportunities to just call when he is the first one to open and you are in MP-LP which should produce the heads-up opportunities you want.
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