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the more someone is going to be paying attention to your play or the more likely villain will be able to pick up on patterns, the more your bet sizing should be consistent with your range as a whole as opposed to the exact two cards in your hand.
so, in very good HS games, a given bet size shouldn't narrow your range so much that it's easy to play perfect against, even if it's on the river in a really specific or even rare situation. river bet sizing against fish at 2nl, however, isn't nearly as sophisticated and can just represent your hole cards. at 25nl against an even remotely thinking reg, your flop cbets need to be consistent wtih a range and shouldn't put your hand face up because flop cbets happen enough for someone to pick up on a pattern. even against bad regs, PF 4b sizing needs to be more or less consistent in HU matches because you will be utilizing that play often enough.
SOOOOO all of this is to say that pre flop raising is SUCH a common play (you will be doing it at least 1 out of every 10 hands), even agianst the biggest of fish at the smallest of limits, PFR sizing should be more or less consistent with the strength of your entire range (there are obviously a million exceptions to this, and i in fact change my iso sizing all the fucking time against different stack sizes and with different hands and against different villains). so, in general, people have certain PFR sizing for certain positions, and don't let what two cards they're holding affect that sizing.
most common for micro limits is opening 4x's in most positions and doing 3-3.5x's in positions where you have a wide range like CO and BU and in BvB.
another way to put it is the more you're in a vacuum in a certain situation (either because it's a super rare spot, or because villain isn't paying attention, or because it's rush poker), the more you can allow your hand to be faceup through your bet sizing.
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