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Of course, it always depends, but to be profitable with marginal hands when flatting from the blinds to an open you have to be really confident in your postflop play (I know it's a generic statement) but if the only thing you know is "TAG 20/16 opens from the CO" then just fold, if you do have more information on his postflop game, and are confident in yours then play them.
Also, with SC, they go up in value the deeper you are, and a must for these hands is to be IP.
I think calling 78s OTB is going to be more profitable than KJo, yet calling KJo form the BB is going to be more profitable than 78s
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