How do you play heads up with semi deepstacks?

I did not use my normal aggressive line against this guy. If he decided to push I did not want to be put to a hard decision. This guy is capable of setting traps, him limping/flat calling with AA preflop would not suprise me. Basically what I want to know, is it common to use extreme caution when heads up against a deep stack. Or do you play the same? I'm usually looking to keep the pot size down unless I have the nuts of course. But hands like TPTK lose value to me. Discuss.

PokerStars No-Limit Hold'em, $2 BB (5 handed) FTR converter on zerodivide.cx

SB ($71.60)
BB ($42.40)
UTG ($113.35)
MP ($520.20)
IOS ($526.70)

Preflop: IOS is Button with Q:spade:, K:club:.
1 fold, MP calls $2, IOS raises to $10, 2 folds, MP calls $8.

Flop: ($23) A:club:, Q:heart:, Q:club: (2 players)
MP checks, IOS bets $12, MP calls $12.

Turn: ($47) 6:diamond: (2 players)
MP checks, IOS bets $21, MP folds.

Final Pot: $68

Results in white below:
No showdown. IOS wins $68.

Just basically don't put your stack on the line without something close to the nuts.