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PokerTracker works on mac, these days. The full version costs $90 (as opposed to Poker Copilot's $70), but you can buy a PokerTracker MicroStakes version for $45, which if fully functional for stakes up to and including $0.10/$0.25 (no limit). Then later on you can pay the other $45 and get the higher stakes unlocked. I'd say PokerTracker is your best bet, having used both (although I haven't used Poker Copilot in the last ~six months). The good news is that Poker Copilot comes with a 30 day trial and I think PokerTracker still comes with a 60 day trial, so you can check both out and decide for yourself which you prefer.
As far as sites are concerned, if you're playing at either PokerStars or Full Tilt Poker then you're fine, they support mac beautifully. Same goes (although to a slightly lesser degree of awesomeness) for sites on the Cereus network (Absolute Poker and UltimateBet/UB) and sites on the OnGame network (a few here, bwin, betfair, tower poker, look around). All those mentioned have a downloadable mac client, there're also other sites that claim to support mac but only through in-browser flash interfaces, and these are pretty weak.
Hope that helps.
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