Without having any reads on a villian, does anyone have a system or trick to know when your good hand is beat?

For example, if I have a full house, but not the nuts, is there any way to reliably predict when I'm beat?

Tonight my system could have been as simple as don't call any all-ins when there's a pair on the board (unless I have the nuts of course). I have to think that this system is WAY too simple and WAY too cautious. I think it will make me give up a good hand too often.

Any suggestions?