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If they have fewer hands, then they have stronger hands on average, and that means that you can't bluff them as often with all else being equal.
With that having been said, pre-flop stats aren't the only thing you have to consider. Is this the type of player who likes to call down three streets against pot-sized bets when they hold third pair with no draw? If so, then it doesn't matter if they're 17/5 or 35/25 because their folding percentage on most boards is going to be pretty low with all else being equal.
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