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Unless you think you can get away with making it different sizes with different hands, I'd recommend having one size for each position, and varying it with the strength of your range, so you might make it 4bb utg and utg+1 with your whole range from those positions, 3bb other positions, and 2.5bb on the button.
I open 99+ in 6max utg, sometimes opening smaller pairs if there is a big fish in the blinds and I feel it's likely I'll isolate them. Opening smaller pps is probably a leak even then, but I sometimes can't resist the temptation - everyone finds it tough to fold pairs I think, but honestly the smaller ones suck when it comes to postflop playability - its impossible to stay aggressive without spewing when you have only 2 outs.
If it's opened in EP by a nit, who likely has a big hand they will at least consider stacking off with, then calling on the button or co is good, even if it will be HU, because you're playing against a strong range that can pay off when you hit. It's easy to overestimate your implied odds, and I am sure I am guilty of that, I think often it's just better to fold - they really do have to be a nit and only be opening stacking-off hands, or be pretty weak-tight postflop so you can get to showdown unimproved against their missed overs sometimes.
Calling behind in lp with multiple callers in front is the best possible spot, as the pot lays you great odds. The only exception would be a really squeeze-happy blind, but even then they probably won't squeeze a tight utg opener + multiple callers. In these kind of pots, you can sometimes even setmine the turn - eg. utg opened and 4 callers + you saw the flop, you miss, utg bets a flop that it's likely a lot of people have a piece of and everyone calls - you can call behind there and have direct pot odds to setmine the turn, but I wouldn't do so with small pairs, as you're too likely to be oversetted - on the rare occasions this does happed, it's probably best only to try this with like TT+
Calling to setmine in ep/mp is generally bad - you can get squeezed behind, and it can easily come back around shoved utg on top of that.
If I've opened, and I'm 3bet by a tight 3better, then I'll call that if stacks are say 15x the size of the call, as again they have a strong range that will pay off.
Lots of variables, as you can see. I'll have to look in my db later and see if I actually make any money with like 55-99, I suspect if I do it's hardly worth it - it's very easy to overestimate the profitability of setmining because we all tend to overestimate our implied odds.
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